The Secret's Out after 22 Years

The Simpsons are from Springfield, Oregon. It must be true. In the Springfield depicted in "The Simpsons", the school is falling apart, there's a constant fire at the town dump, and Mayor Quimby is chronically, helplessly corrupt," said Springfield, Ore., community-relations manager Niel Laudati. "We don't have a nuclear power plant but we do have are a lot of blue-collar working families that go to church every week and eat dinner together."

Father Knows Best was also from Springfield, but I'm not sure that it was the same Springfield.